Journal article
L. Corrie, J. Kaur, A. Awasthi, S. Vishwas, M. Gulati, Sumant Saini, B. Kumar, N. K. Pandey, G. Gupta, H. Dureja, D. Chellapan, K. Dua, Devesh Tewari, Sachin Kumar Singh
Pharmaceutics, 2022
Pharmaceutics, 2022
Semantic Scholar
DOI
PubMedCentral
PubMed
Cite
Cite
APA
Click to copy
Corrie, L., Kaur, J., Awasthi, A., Vishwas, S., Gulati, M., Saini, S., … Singh, S. K. (2022). Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of Curcumin-Loaded Solid SNEDDS: Dissolution and Bioavailability Assessment. Pharmaceutics.
Chicago/Turabian
Click to copy
Corrie, L., J. Kaur, A. Awasthi, S. Vishwas, M. Gulati, Sumant Saini, B. Kumar, et al. “Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of Curcumin-Loaded Solid SNEDDS: Dissolution and Bioavailability Assessment.” Pharmaceutics (2022).
MLA
Click to copy
Corrie, L., et al. “Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of Curcumin-Loaded Solid SNEDDS: Dissolution and Bioavailability Assessment.” Pharmaceutics, 2022.
BibTeX Click to copy
@article{l2022a,
title = {Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of Curcumin-Loaded Solid SNEDDS: Dissolution and Bioavailability Assessment},
year = {2022},
journal = {Pharmaceutics},
author = {Corrie, L. and Kaur, J. and Awasthi, A. and Vishwas, S. and Gulati, M. and Saini, Sumant and Kumar, B. and Pandey, N. K. and Gupta, G. and Dureja, H. and Chellapan, D. and Dua, K. and Tewari, Devesh and Singh, Sachin Kumar}
}
Abstract
The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic curcumin (CUN). GIQ9 has never been explored for solidification of liquid lipid-based nanoparticles such as a liquid isotropic mixture of a SNEDDS containing oil, surfactant and co-surfactant. The suitability of GIQ9 as a carrier was assessed by calculating the loading factor, flow and micromeritic properties. The S-SNEDDSs were prepared by surface adsorption technique. The formulation variables were optimized using central composite design (CCD). The optimized S-SNEDDS was evaluated for differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopy, dissolution and pharmacokinetic studies. The S-SNEDDS showed a particle size, zeta potential and PDI of 97 nm, −26.8 mV and 0.354, respectively. The results of DSC, XRD, FTIR and microscopic studies revealed that the isotropic mixture was adsorbed onto the solid carrier. The L-SNEDDS and S-SNEDDS showed no significant difference in drug release, indicating no change upon solidification. The optimized S-SNEDDS showed 5.1-fold and 61.7-fold enhancement in dissolution rate and oral bioavailability as compared to the naïve curcumin. The overall outcomes of the study indicated the suitability of GIQ9 as a solid carrier for SNEDDSs.