Journal article
Charanjit Kaur, Sanjeev Kumar Sahu, Keshav Bansal, Lindsay K DeLiberto, Jie Zhang, Devesh Tewari, A. Bishayee
Antioxidants and Redox Signaling, 2024
Antioxidants and Redox Signaling, 2024
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APA
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Kaur, C., Sahu, S. K., Bansal, K., DeLiberto, L. K., Zhang, J., Tewari, D., & Bishayee, A. (2024). Targeting Peroxisome Proliferator-Activated Receptor-β/δ, Reactive Oxygen Species and Redox Signaling with Phytocompounds for Cancer Therapy. Antioxidants and Redox Signaling.
Chicago/Turabian
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Kaur, Charanjit, Sanjeev Kumar Sahu, Keshav Bansal, Lindsay K DeLiberto, Jie Zhang, Devesh Tewari, and A. Bishayee. “Targeting Peroxisome Proliferator-Activated Receptor-β/δ, Reactive Oxygen Species and Redox Signaling with Phytocompounds for Cancer Therapy.” Antioxidants and Redox Signaling (2024).
MLA
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Kaur, Charanjit, et al. “Targeting Peroxisome Proliferator-Activated Receptor-β/δ, Reactive Oxygen Species and Redox Signaling with Phytocompounds for Cancer Therapy.” Antioxidants and Redox Signaling, 2024.
BibTeX Click to copy
@article{charanjit2024a,
title = {Targeting Peroxisome Proliferator-Activated Receptor-β/δ, Reactive Oxygen Species and Redox Signaling with Phytocompounds for Cancer Therapy.},
year = {2024},
journal = {Antioxidants and Redox Signaling},
author = {Kaur, Charanjit and Sahu, Sanjeev Kumar and Bansal, Keshav and DeLiberto, Lindsay K and Zhang, Jie and Tewari, Devesh and Bishayee, A.}
}
Abstract
SIGNIFICANCE Peroxisome proliferator-activated receptors (PPARs) have a moderately preserved amino-terminal domain, an extremely preserved DNA-binding domain, an integral hinge region, and a distinct ligand-binding domain that are frequently encountered with the other nuclear receptors. PPAR-β/δ is among the three nuclear receptor superfamily members in the PPAR group.
RECENT ADVANCES Emerging studies provide an insight on natural compounds that have gained increasing attention as potential anticancer agents due to their ability to target multiple pathways involved in cancer development and progression.
CRITICAL ISSUES Modulation of PPAR-β/δ activity has been suggested as a potential therapeutic strategy for cancer management. This review focuses on the ability of bioactive phytocompounds to impact reactive oxygen species and redox signaling in targeting PPAR-β/δ for cancer therapy.
FUTURE DIRECTIONS It is advisable to employ more thorough and detailed methodologies to undertake mechanistic explorations of numerous phytocompounds. Moreover, conducting additional clinical studies is recommended to establish optimal dosages, efficacy, and the impact of different phytochemicals on PPAR-β/δ.