Antiurolithiatic Activity of Daucus carota: An In vitro Study

Journal article

Sweta Bawari, A. Sah, Devesh Tewari
Pharmacognosy Journal, 2018

Cite

APA Click to copy
Bawari, S., Sah, A., & Tewari, D. (2018). Antiurolithiatic Activity of Daucus carota: An In vitro Study. Pharmacognosy Journal.

Chicago/Turabian Click to copy
Bawari, Sweta, A. Sah, and Devesh Tewari. “Antiurolithiatic Activity of Daucus Carota: An In Vitro Study.” Pharmacognosy Journal (2018).

MLA Click to copy
Bawari, Sweta, et al. “Antiurolithiatic Activity of Daucus Carota: An In Vitro Study.” Pharmacognosy Journal, 2018.

BibTeX Click to copy

@article{sweta2018a,
  title = {Antiurolithiatic Activity of Daucus carota: An In vitro Study},
  year = {2018},
  journal = {Pharmacognosy Journal},
  author = {Bawari, Sweta and Sah, A. and Tewari, Devesh}
}

Abstract

Context: Urolithiasis is a polygenic disorder with complex etiology and even complicated treatment outcomes. Daucus carota is a widely cultivated crop with traditional claims for its antiurolithiatic potential. Aim: Present study was an attempt to investigate the antilithic potential of D. carota root extract (DCRE) against calcium oxalate (CaOx) urolithiasis by employing in vitro methods. Methods: Nucleation, growth and aggregation assay of CaOx crystallization were used. FT-IR analysis was used for characterizing CaOx crystals. Results: DCRE exhibited significant inhibition of nucleation, growth and aggregation of CaOx crystals. It produced a favorable morphological transformation of CaOx crystals from calcium oxalate monohydrate to calcium oxalate dihydrate. FT-IR analysis confirmed formation of calcium oxalate monohydrate crystals to be utilized for growth and aggregation assays. Conclusion: DCRE possesses significant antiurolithiatic activity against CaOx urolithiasis in vitro which could be attributed to its saponins, tannins, flavonoids and polyphenolic content.